Benzenamine, 3-(methylthio)- → (3-Methylsulfanyl-phenylamino)-phenyl-acetic acid ethyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Ethyl 2-bromo-2-phenylacetate (0.22 mL, 1.23 mmol), 3-(methylthio)aniline (0.22 mL, 1.85 mmol), and DIPEA (0.32 mL, 1.85 mmol) are dissolved in acetonitrile (3 mL) and heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (petroleum ether/EtOAc=85/15) to obtain intermediate I98 as a colorless oil (292 mg, 79% yield).

Herkunft & Nachweise