HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| Edukt | 4-Methoxybenzene-1,2-diamine dihydrochloride | HCID 3085161 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide | HCID 63257662 | 62,4% |
Reaktionsschritte
Method 6—Step a A mixture of 5-Bromo-2-fluoro-benzoic acid (1.50 g, 6.85 mmol), 4-methoxy-benzene-1,2-diamine dihydrochloride (1.77 g, 8.49 mmol), HATU (2.73 g, 7.19 mmol) and TEA (2.88 mL, 20.76 mmol) in dichloromethane (20 mL) and DMF (5 mL) was stirred at room temperature overnight, then water was added (50 mL), mixture was stirred for 2 h and left standing at room temperature overnight. The precipitate obtained was filtered off and dried to afford 1.45 g of the title compound (50%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08835648B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-d73d945322a94c8a9a3b8a50b768d317 |
| Quellennotiz | uspto-grants-2014_09 |