2-Aminophenol → 4-(Benzo[d]oxazol-2-yl)-2-methoxyphenol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

4-hydroxy-3-methoxybenzoic acid (25 g, 149 mmol) and 2-amino phenol (16.2 g, 149 mmol) were combined in a round bottom flask. Trimethylsilyl polyphosphate (80 mL) was added neat. The mixture was heated at 180° C. for 30 min. The mixture is poured over ice and allowed to stir overnight. The suspension was filtered to afford 4-(1,3-benzoxazol-2-yl)-2-methoxyphenol as a pale green solid. MS (ESI) 242 (M+H)+.

Herkunft & Nachweise