N-benzyloxycarbonyl-beta-benzyl-L-aspartyl-D-valine (R)-alpha-ethoxymethylbenzylamide → alpha-L-aspartyl-D-valine (R)-alpha-ethoxymethylbenzylamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a suspension of 1.20 g (1.99 mmols) of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide in 50 ml of methanol and 10 ml of water was added 0.30 g of 10% Pd-carbon (water content 50%). The mixture was reduced under hydrogen under heat at 40°C., 40 ml of water was added thereto, the catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure to 5 ml. The crystal thus precipitated was removed by filtration and dried to obtain 0.38 g (1.00 mmol, 50.3%) of α-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide.

Herkunft & Nachweise