Phosphorus oxychloride → 2-Chloro-3-iodo-5-nitropyridine
Reaktionsgleichung
[I:1][C:2]1[C:3](O)=[N:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:3]1[C:2]([I:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[CH:5][N:4]=1Komponenten
3
Versuchsvorschrift
3-Iodo-5-nitropyridin-2-ol (3.00 g, 0.0113 mol) was heated to reflux in phosphoryl chloride (15 mL, 0.1609 mol) for 4 hours. The reaction was quenched in ice/water and was neutralized with Na2CO3. The reaction was extracted with ethyl acetate and the organic extracts were washed with water, saturated NaCl, dried (MgSO4) and stripped in vacuo to give the product, which was used in the next reaction without purification.
Aufarbeitung
- customThe reaction was quenched in ice/water
- extractionThe reaction was extracted with ethyl acetate
- washthe organic extracts were washed with water, saturated NaCl
- dry with materialdried (MgSO4)
- customto give the product, which
- customwas used in the next reaction without purification
Quellen und Nachweise
- ORD-Eintrag
- ord-4f25e1129fd24f0cb896bcefa30ff55b
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08841318B2
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