Triethylamine → 5-Iodo-6-methylpyridin-3-yl-3-(trifluoromethyl)benzamide

HRID 77733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 77733
[I:1][C:2]1[CH:3]=[C:4](N)[CH:5]=[N:6][C:7]=1[CH3:8].C([N:12](CC)CC)C.[F:17][C:18]([F:29])([F:28])[C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22](Cl)=[O:23]>C(Cl)Cl>[I:1][C:2]1[CH:3]=[C:4]([C:20]2[C:19]([C:18]([F:29])([F:28])[F:17])=[CH:27][CH:26]=[CH:25][C:21]=2[C:22]([NH2:12])=[O:23])[CH:5]=[N:6][C:7]=1[CH3:8]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 591982915-Iodo-6-methylpyridin-3-amine

Produkt 1

HCID 866991415-Iodo-6-methylpyridin-3-yl-3-(trifluoromethyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 5-iodo-6-methylpyridin-3-amine (125 mg, 0.534 mmol) in methylene chloride (1 mL) was added triethylamine (0.087 mL, 0.627 mmol) and cooled at 0° C. Into the reaction was added 3-(trifluoromethyl)benzoyl chloride (0.0812 mL, 0.538 mmol) dropwise and stirred at 0° C. for 45 minutes and at 25° C. for 16 hours. The reaction was extracted with EtOAc and the organic extracts were washed with water saturated Na2CO3, saturated NaCl, dried (MgSO4) and stripped in vacuo. The product was used in the next reaction without purification.

Aufarbeitung

  1. extractionThe reaction was extracted with EtOAc
  2. washthe organic extracts were washed with water saturated Na2CO3, saturated NaCl
  3. dry with materialdried (MgSO4)
  4. customThe product was used in the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-12d4c92d7f6b4c978975e1ea8978481d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841318B2

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