Methoxyisopropylamine → 4'-Methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid
Reaktionsgleichung
COCC(N[C:7]([C:9]1[CH:10]=[C:11]([C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)[CH:12]=[C:13]([N:15]2[C:19]([C:20]([F:23])([F:22])[F:21])=[N:18][N:17]=[N:16]2)[CH:14]=1)=[O:8])C.C[O:32]CC(N)C>>[CH3:30][C:27]1[CH:26]=[CH:25][C:24]([C:11]2[CH:12]=[C:13]([N:15]3[C:19]([C:20]([F:23])([F:22])[F:21])=[N:18][N:17]=[N:16]3)[CH:14]=[C:9]([C:7]([OH:8])=[O:32])[CH:10]=2)=[CH:29][CH:28]=1Komponenten
3
Versuchsvorschrift
4′-Methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide was reacted with 2-methoxy-1-methyl-ethylamine using the procedure of step 4 of Example 3 to give 4′-methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid. MS (M+H)=420.
Quellen und Nachweise
- ORD-Eintrag
- ord-fa222cff1b8f410d91fea95db555e6cf