Ammonia → 2-Amino-6-chloronicotinic acid

HRID 77844

Reaktionsgleichung

Reaktionsgleichung von HRID 77844
Cl[C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH3:12]>>[NH2:12][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 8540472,6-Dichloronicotinic acid

Produkt 1

HCID 122639922-Amino-6-chloronicotinic acidAusbeute 49 %

Reaktionsbedingungen

Temperatur
135 °C

Versuchsvorschrift

A mixture of 2,6-dichloro-nicotinic acid (31 g, 0.14 mol) and 28% aqueous ammonia solution (200 mL) was stirred in a sealed tube for 10 hours at 135° C. This reaction solution was cooled to room temperature, and the excess ammonia gas was removed under a reduced pressure. Water was added to the residue to a total of 1000 mL, the mixture was cooled to 0° C., and citric acid was added to a pH being about 6. The precipitated solids were filtered out to obtain the title compound (12 g, 49%).

Aufarbeitung

  1. temperatureThis reaction solution was cooled to room temperature
  2. customthe excess ammonia gas was removed under a reduced pressure
  3. additionWater was added to the residue to a total of 1000 mL
  4. temperaturethe mixture was cooled to 0° C.
  5. additioncitric acid was added to a pH
  6. filtrationThe precipitated solids were filtered out

Quellen und Nachweise

ORD-Eintrag
ord-c6bcdac826aa4bd2aef409a03fd677ce
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841327B2

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