HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cyclohexene → 5-[3-(4-Aminophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cyclohexene | HCID 8079 | — |
| Edukt | 5-[3-(4-Nitrophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole | HCID 21992365 | — |
| Katalysator | HCID 178418390 | HCID 178418390 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 5-[3-(4-Aminophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole | HCID 21992411 | 103% |
Reaktionsschritte
45 mg of 5-[3-(4-nitrophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole was dissolved in 6 ml of methanol, followed by the addition of 2 ml of cyclohexene. Then, 45 mg of 10% palladium-carbon was added thereto, followed by heating under reflux for 2 hours. After the reaction mixture was filtered, the filtrated was concentrated to obtain 43 mg of the title compound quantitatively as a colorless amorphous substance.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07087624B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-30692bebc63d4f1ebbff40f9277d3172 |
| Quellennotiz | uspto-grants-2006_08 |