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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 7801Erstellt: 25. Oktober 2026

Cyclohexene → 5-[3-(4-Aminophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole

https://huagongshe.com/reaction/7801

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktCyclohexeneHCID 8079—
Edukt5-[3-(4-Nitrophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazoleHCID 21992365—
KatalysatorHCID 178418390HCID 178418390—
LösungsmittelMethanolHCID 887—
Produkt5-[3-(4-Aminophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazoleHCID 21992411103%

Reaktionsschritte

45 mg of 5-[3-(4-nitrophenyl)propyl]-3-(4-fluorophenyl)-1-methyl-4-(4-pyridyl)pyrazole was dissolved in 6 ml of methanol, followed by the addition of 2 ml of cyclohexene. Then, 45 mg of 10% palladium-carbon was added thereto, followed by heating under reflux for 2 hours. After the reaction mixture was filtered, the filtrated was concentrated to obtain 43 mg of the title compound quantitatively as a colorless amorphous substance.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07087624B2
Quelldatensatzuspto-grants-2006_08
ORD IDord-30692bebc63d4f1ebbff40f9277d3172
Quellennotizuspto-grants-2006_08