(4-(2-Furan-2-yl-ethyl)-phenyl)-methanol → HCID 59255346, Verbindung

HRID 78029Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 78029
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][CH:9]=1>[O-2].[O-2].[Mn+4].C(OCC)(=O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]=[O:15])=[CH:12][CH:13]=1

Komponenten

4

Edukt 1

HCID 59255362(4-(2-Furan-2-yl-ethyl)-phenyl)-methanol

Produkt 1

HCID 59255346HCID 59255346, VerbindungAusbeute 83,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To an ethyl acetate (50 mL) solution of (4-(2-furan-2-yl-ethyl)-phenyl)-methanol (580 mg, 2.87 mmol) described in Manufacturing Example 80-1-3 was added activated manganese dioxide (8 g, 92 mmol), which was stirred for 12 hours at room temperature. The reaction solution was suction filtered through a Celite pad, and washed with ethyl acetate (50 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (480 mg, 83.5%).

Aufarbeitung

  1. filtrationfiltered through a Celite pad
  2. washwashed with ethyl acetate (50 mL)
  3. concentrationThe filtrate was concentrated under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-94883085df7a450b918af47e01289284
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841327B2

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