HCID 59255084, Verbindung → HCID 59255317, Verbindung

HRID 78067Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 78067
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=1>[O-2].[O-2].[Mn+4].C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]=[O:14])=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 59255084HCID 59255084, Verbindung

Produkt 1

HCID 59255317HCID 59255317, VerbindungAusbeute 82,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To an ethyl acetate (100 mL) solution of 4-(2-pyridin-2-yl-ethyl)benzyl alcohol (3.16 g, 14.8 mmol) described in Manufacturing Example 93-1-4 was added activated manganese dioxide (45 g, 518 mmol), which was stirred for 4 hours at room temperature. The reaction mixture was filtered through a Celite pad, and washed with ethyl acetate (100 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (2.57 g, 82%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a Celite pad
  2. washwashed with ethyl acetate (100 mL)
  3. concentrationThe filtrate was concentrated under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a58003514eac4b91b80a51f91b68160c
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841327B2

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