Tetrahydrofuran → HCID 59255475, Verbindung
Reaktionsgleichung
[C:1]([C:3]1[C:4]([NH2:9])=[N:5][CH:6]=[CH:7][CH:8]=1)#[CH:2].[C:10]1([S:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21](CC(Cl)=NO)=[CH:20][CH:19]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH2:29]([N:31](CC)CC)[CH3:30].[O:36]1CCCC1>>[CH2:17]([S:16][C:10]1[CH:11]=[CH:12][C:13]([CH2:30][C:29]2[CH:2]=[C:1]([C:3]3[C:4]([NH2:9])=[N:5][CH:6]=[CH:7][CH:8]=3)[O:36][N:31]=2)=[CH:14][CH:15]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1Komponenten
Versuchsvorschrift
To a tetrahydrofuran (3 mL) solution of 3-ethynyl-pyridin-2-ylamine (50 mg, 0.423 mmol) described in Manufacturing Example 1-2-3 and (4-phenylsulfanylmethyl-phenyl)acetohydroximoyl chloride (197 mg, 0.677 mmol) described in Manufacturing Example 205-1-6 was added triethylamine (147 μL, 1.06 mmol), which was stirred for 18 hours at room temperature. This mixture was cooled to room temperature and partitioned into ethyl acetate and water. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure, and the residue was purified by NH silica gel column chromatography (ethyl acetate:heptane=1:4 to 1:2) to obtain the title compound (29 mg, 18%).
Aufarbeitung
- temperatureThis mixture was cooled to room temperature
- custompartitioned into ethyl acetate and water
- customThe organic layer was separated
- washwashed with water
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationThe filtrate was concentrated under a reduced pressure
- customthe residue was purified by NH silica gel column chromatography (ethyl acetate:heptane=1:4 to 1:2)
Quellen und Nachweise
- ORD-Eintrag
- ord-567698f7eef24bb7af68d0824d0d4e75
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08841327B2
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