4-Amino-2-chlorophenol → 4-(2-(N-methylcarbamoyl)4-pyridyloxy)-3-chloroaniline

HRID 78366

Reaktionsgleichung

Reaktionsgleichung von HRID 78366
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Cl:9])[CH:3]=1.Cl[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([C:17]([NH:19][CH3:20])=[O:18])[CH:12]=1>>[CH3:20][NH:19][C:17]([C:13]1[CH:12]=[C:11]([O:8][C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][C:4]=2[Cl:9])[CH:16]=[CH:15][N:14]=1)=[O:18]

Komponenten

3

Edukt 2

HCID 775784-Amino-2-chlorophenolHCID 14768144-Chloro-N-methylpicolinamide

Produkt 1

HCID 236145624-(2-(N-methylcarbamoyl)4-pyridyloxy)-3-chloroaniline

Versuchsvorschrift

Entry 52: According to Method A2, Step 4, 4-amino-2-chlorophenol was reacted with 4-chloro-N-methyl-2-pyridinecarboxamide, which had been synthesized according to Method A2, Step 3b, to give 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)-3-chloroaniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)-3-chloroaniline to afford the urea.

Aufarbeitung

  1. customhad been synthesized

Quellen und Nachweise

ORD-Eintrag
ord-aee74da1bb3f4b4599e297c262059df5
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841330B2

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