Thionyl Chloride → 5-Fluoro-2-methylbenzoyl chloride
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]Komponenten
3
Versuchsvorschrift
A solution of 5-fluoro-2-methylbenzoic acid (380 mg, 2.47 mmol) in thionyl chloride (5 mL) was heated to reflux for 3 hours. The solution was cooled to ambient temperature and the volatile components were removed under reduced pressure. The residue was dissolved in fresh toluene (10 mL) and concentrated under reduced pressure twice and then placed under high vacuum to afford the title compound (420 mg).
Aufarbeitung
- temperatureto reflux for 3 hours
- customthe volatile components were removed under reduced pressure
- dissolutionThe residue was dissolved in fresh toluene (10 mL)
- concentrationconcentrated under reduced pressure twice
Quellen und Nachweise
- ORD-Eintrag
- ord-fdb9a3548b704bb7936d45fb4cc7b307
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08841334B2
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