Thionyl Chloride → 5-Fluoro-2-methylbenzoyl chloride

HRID 78404

Reaktionsgleichung

Reaktionsgleichung von HRID 78404
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 1821145-Fluoro-2-methylbenzoic acid

Produkt 1

HCID 27373835-Fluoro-2-methylbenzoyl chloride

Versuchsvorschrift

A solution of 5-fluoro-2-methylbenzoic acid (380 mg, 2.47 mmol) in thionyl chloride (5 mL) was heated to reflux for 3 hours. The solution was cooled to ambient temperature and the volatile components were removed under reduced pressure. The residue was dissolved in fresh toluene (10 mL) and concentrated under reduced pressure twice and then placed under high vacuum to afford the title compound (420 mg).

Aufarbeitung

  1. temperatureto reflux for 3 hours
  2. customthe volatile components were removed under reduced pressure
  3. dissolutionThe residue was dissolved in fresh toluene (10 mL)
  4. concentrationconcentrated under reduced pressure twice

Quellen und Nachweise

ORD-Eintrag
ord-fdb9a3548b704bb7936d45fb4cc7b307
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

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