Benzene, (2-bromoethoxy)- → 4,5-Dimethyl-3-(2-phenoxy-ethyl)-3H-thiazol-2-ylideneamine hydrobromide

HRID 78406

Reaktionsgleichung

Reaktionsgleichung von HRID 78406
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[Br:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[BrH:9].[CH3:1][C:2]1[N:3]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

Komponenten

3

Edukt 2

HCID 68526Benzene, (2-bromoethoxy)-HCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Produkt 1

HCID 686212084,5-Dimethyl-3-(2-phenoxy-ethyl)-3H-thiazol-2-ylideneamine hydrobromideAusbeute 50,6 %

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A mixture of 4,5-dimethylthiazol-2-ylamine (1.0 g, 7.8 mmol) and (2-bromo-ethoxy)benzene (1.9 g, 9.4 mmol) were heated neat to 85° C. for 19 hours. The mixture was cooled to ambient temperature and the residue was crystallized from isopropanol. The solid was collected by filtration and dried under vacuum to afford 1.3 g (50%) of the title compound. MS (DCI/NH3) m/z 249 (M+H)+.

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe residue was crystallized from isopropanol
  3. filtrationThe solid was collected by filtration
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-83cb530fe84542689d937de7db6523a9
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

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