2-Amino-4,5-dimethyl-1,3-thiazole → 4,5-Dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylideneamine hydrobromide

HRID 78457

Reaktionsgleichung

Reaktionsgleichung von HRID 78457
[NH2:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[Br:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1>>[BrH:9].[CH3:7][C:5]1[N:6]([CH2:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][O:12]2)[C:2](=[NH:1])[S:3][C:4]=1[CH3:8]

Komponenten

3

Edukt 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 1419172-(Bromomethyl)tetrahydro-2H-pyran

Produkt 1

HCID 668593534,5-Dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylideneamine hydrobromide

Versuchsvorschrift

A mixture of 2-amino-4,5-dimethylthiazole and 2-(bromomethyl)tetrahydro-2H-pyran were processed using the method described in Example 12A to afford the title compound 1H NMR (300 MHz, DMSO-d6) δ ppm 1.13-1.31 (m, 1H) 1.36-1.52 (m, 3H) 1.64-1.85 (m, 2H) 2.18 (d, J=4 Hz, 6H) 3.19-3.33 (m, 1H) 3.49-3.63 (m, 1H) 3.77-3.89 (m, 1H) 3.94-4.02 (m, 2H) 9.34 (s, 2H),), MS (DCI/NH3) m/z 227 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-8265d65ced604241a193077df6b8e23d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

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