4-Hydroxybenzaldehyde → 4-[2-(1,3-Dioxolan-2-yl)ethoxy]benzaldehyde

In a 500 ml flask, 120 ml of acetonitrile, 13.8 g of 4-hydroxybenzaldehyde, 19.9 g of 2-(2-bromoethyl)-1,3-dioxane, 1.8 g of potassium iodide, and 35.8 g of potassium carbonate were placed and then, reacted at 80° C. for 5 hr. Thereafter, to the reaction mixture was added 200 ml of ethyl acetate and washed once with a saturated aqueous potassium carbonate solution, distilled water and saturated saline. The washed organic phase was dried over anhydrous magnesium sulfate and the solvent was removed, to give 23.7 g of 4-(2-[1,3]-dioxolan-2-yl-ethoxy)benzaldehyde.

1. customreacted at 80° C. for 5 hr
2. washwashed once with a saturated aqueous potassium carbonate solution
3. distillationdistilled water and saturated saline
4. dry with materialThe washed organic phase was dried over anhydrous magnesium sulfate
5. customthe solvent was removed

ORD-Eintrag

ord-ab767623531e408bb0c0320b5128145a

Quelldatensatz

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05723258