Propargyl bromide → 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.

Herkunft & Nachweise