Propargyl bromide → 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide

HRID 78534

Reaktionsgleichung

Reaktionsgleichung von HRID 78534
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[C:10]#[CH:11]>C1(C)C=CC=CC=1.C(OCC)C>[BrH:12].[CH3:1][C:2]1[N:3]([CH2:11][C:10]#[CH:9])[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

Komponenten

5

Edukt 2

HCID 7842Propargyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Produkt 1

HCID 866408574,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromideAusbeute 72,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.

Aufarbeitung

  1. temperaturethen cooled
  2. filtrationthe solid was collected via filtration

Quellen und Nachweise

ORD-Eintrag
ord-b6f5b5843ebb4d588a2e5b6422eff13e
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

Verknüpfte Notizen

Wird geladen…