2-Bromoethyl methyl ether → 5-(4,4-Difluorocyclohexyl)-3-(2-methoxyethyl)thiazol-2(3h)-imine hydrobromide
Reaktionsgleichung
[F:1][C:2]1([F:14])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][CH:11]([NH2:13])[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:15][O:16][CH2:17][CH2:18][Br:19]>>[BrH:19].[F:14][C:2]1([F:1])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][C:11](=[NH:13])[N:10]([CH2:18][CH2:17][O:16][CH3:15])[CH:9]=2)[CH2:4][CH2:3]1Komponenten
3
Versuchsvorschrift
A mixture of Example 370E and commercially available 2-bromoethyl methyl ether (Aldrich) was processed using the method described in Example 12A to afford the title compound. MS (ESI−) m/z 277 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-47651e57d76a403daa75c299751455f0
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08841334B2
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