Sodium Hydroxide → 6-amino-1-(2-isocyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To 3-(2-cyano-acetyl)-3-methyl-1-(2-isocyanobenzyl)-urea (120 g) were added water (962 ml) and 2N aqueous sodium hydroxide solution (24.9 ml), and the mixture was stirred with heating at 80° C. for 1 hr. After allowing to cool to room temperature, the crystals were collected by filtration and dried to give 6-amino-1-(2-isocyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione in 76% yield.

Herkunft & Nachweise