HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-iodo-benzyl)-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | 4-Iodobenzaldehyde | HCID 96657 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-iodo-benzyl)-amine | HCID 66631770 | 81,4% |
Reaktionsschritte
Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.04 g, 0.15 mmol) was reacted with 4-iodobenzaldehyde (0.045 g, 0.15 mmol) in the presence of glacial acetic acid (0.009 g, 0.15 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.012 g, 0.18 mmol) in methanol (5 ml) (Procedure D) to give compound 16m (0.059 g, 81%) as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08841464B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-09f23557bf58494cbcf4b68d8ff338c4 |
| Quellennotiz | uspto-grants-2014_09 |