p-Fluorophenethylamine → (2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol

https://huagongshe.com/de/reaction/78934

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	p-Fluorophenethylamine	HCID 4653	—
Edukt	(1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane	HCID 54762329	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	(2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol	HCID 11315715	—

Reaktionsschritte

(1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28a (0.025 g, 0.094 mmol) was reacted with 2-(4-fluoro-phenyl)-ethylamine (0.26 g, 1.88 mmol) in ethanol (Procedure E) to yield (2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol, (−)-29c, 0.04 g (98%, [α]D=(−)62.9, c=1, MeOH).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08841464B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-436e06b4e72843c5bb0ba028063952e6
Quellennotiz	uspto-grants-2014_09