HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-Fluorophenethylamine → (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-Fluorophenethylamine | HCID 4653 | — |
| Edukt | (1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 86605347 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol | HCID 11350257 | — |
Reaktionsschritte
(1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28c (0.02 g, 0.075 mmol) was reacted with 2-(4-fluorophenyl)-ethylamine (0.21 g, 1.50 mmol) in ethanol (Procedure E) to yield (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol, (+)-29c, 0.030 g (98%, [α]D=(+)63.4, c=1, MeOH).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08841464B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-67d7c88ad0b64a8ea092e55a87a005fe |
| Quellennotiz | uspto-grants-2014_09 |