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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 7923Erstellt: 23. Oktober 2026

1-Methylpiperazine → 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

https://huagongshe.com/de/reaction/7923

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt1-MethylpiperazineHCID 53167—
Edukt2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-meth anesulfonyloxymethyl-2H-pyridazin-3-oneHCID 21991618—
Edukt4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 67214099—
Produkt2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 2199140273,8%

Reaktionsschritte

Following the procedure of Example 1 (10), 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 73.8%).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07087606B2
Quelldatensatzuspto-grants-2006_08
ORD IDord-af59a80c4f7f4dd69a14246df32e874b
Quellennotizuspto-grants-2006_08