4-carboxy-2-cyclopropylmethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one → 2-cyclopropylmethyl-4-hydroxymethyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one

HRID 7991

Reaktionsgleichung

FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:53])[N:37]([CH2:49][CH:50]2[CH2:52][CH2:51]2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:40]=1)(O)=[O:33]>>[CH:50]1([CH2:49][N:37]2[C:36](=[O:53])[C:35]([CH2:32][OH:33])=[CH:40][C:39]([C:41]3[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=3)=[N:38]2)[CH2:52][CH2:51]1

Komponenten

Edukt 2

HCID 219914244-carboxy-2-cyclopropylmethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one

Produkt 1

HCID 219915922-cyclopropylmethyl-4-hydroxymethyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-oneAusbeute 22,6 %

Versuchsvorschrift

Following the procedure of Example 1 (8), 4-carboxy-2-cyclopropylmethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow crystalline powder (yield: 22.6%).

Aufarbeitung

customwas reacted

Quellen und Nachweise

ORD-Eintrag: ord-45b35999b6f84963bf5a02dbc2d4b406
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07087606B2

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