1-(2-Hydroxyethyl)piperazine → 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(2-Hydroxyethyl)piperazine	HCID 7677	—
Edukt	4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one	HCID 67214099	—
Edukt	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methane sulfonyloxymethyl-2H-pyridazin-3-one	HCID 73858284	—
Produkt	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one	HCID 67213400	65,1%

Reaktionsschritte

Following the procedure of Example 1 (10), 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-piperazineethanol were reacted to yield the title compound as slightly-yellow needles (yield: 65.1%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07087606B2
Quelldatensatz	uspto-grants-2006_08
ORD ID	ord-05e673c9e6fa437aa9ab215ba6dafd87
Quellennotiz	uspto-grants-2006_08