3,5-Dimethylisoxazole-4-boronic acid → 4-[5-(3,5-Dimethylisoxazol-4-yl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80424

Reaktionsgleichung

Reaktionsgleichung von HRID 80424
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[CH3:19][C:20]1[C:24](B(O)O)=[C:23]([CH3:28])[O:22][N:21]=1>>[CH3:19][C:20]1[C:24]([C:2]2[CH:3]=[C:4]([N:8]3[CH2:16][CH:15]4[CH2:17][N:11]5[CH2:12][CH:13]([CH2:18][CH:9]3[CH2:10]5)[CH2:14]4)[CH:5]=[N:6][CH:7]=2)=[C:23]([CH3:28])[O:22][N:21]=1

Komponenten

3

Edukt 2

HCID 27343463,5-Dimethylisoxazole-4-boronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Produkt 1

HCID 498694294-[5-(3,5-Dimethylisoxazol-4-yl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

Versuchsvorschrift

The title compound was prepared from the product of Example 65A and 3,5-dimethylisoxazol-4-ylboronic acid according to General Method B: LC-MS Method B (ESI+) m/z 325.0 (M+H)+, retention time 1.61 minutes.

Quellen und Nachweise

ORD-Eintrag
ord-4ee878eb6a984bd6b6f15a0508afa786
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846661B2

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