HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Edukt | 3-Nitrophenylhydrazinium(1+) chloride | HCID 5464285 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 656969 | — |
Reaktionsschritte
Similar to Example 1, m-nitrophenylhydrazine hydrochloride (10 mmol, 1.9 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a 50% solution of pyridine in ethanol. A precipitate was formed in the reaction medium, and was collected by filtration. Analysis confirmed synthesis of the named product, m.p., 107.7° C.–109.2° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07087634B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-429914abd99c47c1b147ebf79f741665 |
| Quellennotiz | uspto-grants-2006_08 |