2-chloro-N,N-dimethylacetamide → N,N-Dimethyl-2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}acetamide, hydrochloride

HRID 80906

Reaktionsgleichung

Reaktionsgleichung von HRID 80906
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.[Cl:23][CH2:24][C:25]([N:27]([CH3:29])[CH3:28])=[O:26]>>[ClH:23].[CH3:28][N:27]([CH3:29])[C:25](=[O:26])[CH2:24][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:8][CH:7]=3)=[CH:14][N:13]=2)[CH2:16][CH2:17]1

Komponenten

3

Edukt 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

Produkt 1

HCID 131730776N,N-Dimethyl-2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}acetamide, hydrochloride

Versuchsvorschrift

The title compound was prepared by a similar procedure to that described in Example 55, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 2-chloro-N,N-dimethylacetamide.

Quellen und Nachweise

ORD-Eintrag
ord-af128aaa1a814d6aaba34bfafaf11f2a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846677B2

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