4-Acetamidophenylboronic acid → N-{4-[6-(4-Isopropylperhydro-1,4-diazepin-1-yl)pyridazin-3-yl]phenyl}acetamide, dihydrochloride
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:18]([NH:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)(=[O:20])[CH3:19]>>[ClH:1].[ClH:1].[CH:15]([N:11]1[CH2:12][CH2:13][CH2:14][N:8]([C:5]2[N:6]=[N:7][C:2]([C:25]3[CH:26]=[CH:27][C:22]([NH:21][C:18](=[O:20])[CH3:19])=[CH:23][CH:24]=3)=[CH:3][CH:4]=2)[CH2:9][CH2:10]1)([CH3:17])[CH3:16]Komponenten
3
Versuchsvorschrift
The title compound was prepared by a similar procedure to that described in Example 68, starting from 1-(6-chloro-pyridazin-3-yl)-4-isopropyl-perhydro-1,4-diazepine and 4-acetamidophenylboronic acid. 1H NMR (400 MHz, CD3OD) δ 8.43 (d, 1H), 8.03 (d, 1H), 7.94 (m, 2H), 7.84 (m, 2H), 4.36 (m, 1H), 4.17 (m, 1H), 4.03 (m, 1H), 3.73 (m, 4H), 3.42 (m, 2H), 2.50 (m, 1H), 2.39 (m, 1H), 2.17 (s, 3H), 1.41 (d, 6H).
Quellen und Nachweise
- ORD-Eintrag
- ord-56b292da5fac46cdb92f965bc2472e2d
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846677B2
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