4-Acetamidophenylboronic acid → N-{4-[6-(4-Cyclopropyl-[1,4]diazepan-1-yl)pyridazin-3-yl]phenyl}acetamide, dihydrochloride

HRID 80922

Reaktionsgleichung

Reaktionsgleichung von HRID 80922
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([CH:15]3[CH2:17][CH2:16]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:18]([NH:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)(=[O:20])[CH3:19]>>[ClH:1].[ClH:1].[CH:15]1([N:11]2[CH2:12][CH2:13][CH2:14][N:8]([C:5]3[N:6]=[N:7][C:2]([C:25]4[CH:26]=[CH:27][C:22]([NH:21][C:18](=[O:20])[CH3:19])=[CH:23][CH:24]=4)=[CH:3][CH:4]=3)[CH2:9][CH2:10]2)[CH2:17][CH2:16]1

Komponenten

3

Edukt 2

HCID 27346574-Acetamidophenylboronic acidHCID 872861831-(6-Chloro-pyridazin-3-yl)-4-cyclopropyl-perhydro-1,4-diazepine

Produkt 1

HCID 131730780N-{4-[6-(4-Cyclopropyl-[1,4]diazepan-1-yl)pyridazin-3-yl]phenyl}acetamide, dihydrochloride

Versuchsvorschrift

The title compound was prepared by a similar procedure to that described in Example 68, starting from 1-(6-chloro-pyridazin-3-yl)-4-cyclopropyl-perhydro-1,4-diazepine and 4-acetamidophenylboronic acid. 1H NMR (400 MHz, CD3OD) δ 8.47 (d, 1H), 8.08 (d, 1H), 7.94 (d, 2H), 7.85 (d, 2H), 4.33 (broad m, 1H), 4.12 (broad m, 1H), 3.91 (broad m, 4H), 3.62 (broad m, 2H), 2.97 (hept, 1H), 2.55 ((broad m, 1H), 2.43 (broad m, 1H), 2.17 (s, 3H), 1.24 (broad m, 2H), 1.01 (d, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-8a4d099e74044e5986736d68ebe9a625
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846677B2

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