Dimethylformamide → 5-Bromo-1-(cyclopropylmethyl)-1,2-dihydropyridin-2-one

Temperatur

70 °C

KOtBu (0.68 g) was added to a solution of 5-bromo-1H-pyridin-2-one (1.00 g) in tetrahydrofuran (20 mL) at room temperature. After stirring for 30 min, cyclopropylmethyl bromide (0.77 mL) and N,N-dimethylformamide (3 mL) were added to the suspension and the resulting mixture was warmed to 70° C. After stirring the mixture at 70° C. for 2 h, the reaction was finished. The mixture was cooled to room temperature, diluted with ethyl acetate (50 mL), and washed with water (2×20 mL) and brine (20 mL). Then, the solution was dried (MgSO4) and the solvent was removed to give the title compound as a colorless oil.

1. stirringAfter stirring the mixture at 70° C. for 2 h
2. temperatureThe mixture was cooled to room temperature
3. washwashed with water (2×20 mL) and brine (20 mL)
4. dry with materialThen, the solution was dried (MgSO4)
5. customthe solvent was removed

ORD-Eintrag

ord-0b23650c1b574f3fb3190dbcc701bae9

Quelldatensatz

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08846668B2