Sodium Hydroxide → (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

HRID 81488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81488
CC(C)(C)C([NH:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1)=O.[OH-].[Na+]>Cl>[NH2:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 686311822,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide

Produkt 1

HCID 53678495(2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 2,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide (0.225 g, 0.79 mmol) in 3M HCl (10 ml) is heated at reflux for 4 hours. The reaction mixture is allowed to cool to room temperature and the pH adjusted to basic with 2M NaOH. The product is extracted into DCM, dried (MgSO4), and concentrated in vacuo to afford a yellow solid. Drying in vacuo at 45° C. overnight yields (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone [M+H]+ 200.

Aufarbeitung

  1. temperatureat reflux for 4 hours
  2. extractionThe product is extracted into DCM
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customto afford a yellow solid
  6. customDrying in vacuo at 45° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-3147b6d8ef0a4ebe9c6078be1d95b6ee
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846687B2

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