HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → tert-Butyl [2,6-dimethyl-4-(5-methylsulfanyl-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl)-phenoxy]acetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | tert-Butyl bromoacetate | HCID 79177 | — |
| Edukt | 2,6-Dimethyl-4-(5-methylsulfanyl-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl)phenol | HCID 136389866 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | tert-Butyl [2,6-dimethyl-4-(5-methylsulfanyl-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl)-phenoxy]acetate | HCID 86688232 | — |
Reaktionsschritte
3.20 g of potassium carbonate and then 0.93 ml of tert-butyl bromoacetate were added to a solution of 2.00 g of 2,6-dimethyl-4-(5-methylsulfanyl-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl)phenol in 20 ml of N,N-dimethylformamide. The mixture was reacted at 60° C. for 1 h and then allowed to cool and poured into water. The precipitate obtained was filtered off with suction and dried under reduced pressure. This gave 2.45 g of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846691B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-1fe2590e9b5b43a697d634712d8aefba |
| Quellennotiz | uspto-grants-2014_09 |