Trifluoroacetic acid → {4-[5-(trans-2-Fluorocyclohexyloxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acid

HRID 81508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81508
[F:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[O:8][C:9]1[N:10]=[C:11]([O:35][CH2:36][CH2:37][CH3:38])[C:12]2[N:17]=[C:16]([C:18]3[CH:32]=[C:31]([CH3:33])[C:21]([O:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[C:20]([CH3:34])[CH:19]=3)[O:15][C:13]=2[N:14]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[O:8][C:9]1[N:10]=[C:11]([O:35][CH2:36][CH2:37][CH3:38])[C:12]2[N:17]=[C:16]([C:18]3[CH:19]=[C:20]([CH3:34])[C:21]([O:22][CH2:23][C:24]([OH:26])=[O:25])=[C:31]([CH3:33])[CH:32]=3)[O:15][C:13]=2[N:14]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86679899tert-Butyl {4-[5-(trans-2-fluorocyclohexyloxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate

Produkt 1

HCID 53311354{4-[5-(trans-2-Fluorocyclohexyloxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

98 mg of tert-butyl {4-[5-(trans-2-fluorocyclohexyloxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate were dissolved in 3.5 ml of dichloromethane, and treated with 1.5 ml of trifluoroacetic acid. After 16 h, the mixture was concentrated and freeze-dried. This gave 96 mg of the title compound.

Aufarbeitung

  1. concentrationthe mixture was concentrated
  2. customfreeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-f0958e3722c34ea09d4c1cfa459f08ff
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846691B2

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