Hydrochloric Acid → Sodium Chloride

HRID 81618Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81618
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8](OC)=[CH:7][N:6]=1)=[O:4].[OH-:14].[Na+:15].[ClH:16].[C:17]1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][C:7]([O:14][CH3:17])=[CH:8][N:9]=1.[Cl-:16].[Na+:15]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 53438909Methyl 3-amino-5-methoxypyrazine-2-carboxylate

Produkt 2

HCID 5234Sodium ChlorideHCID 167380163-Amino-6-methoxypyrazine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 200 mg (1.092 mmol) 3-amino-5-methoxy-pyrazine-2-carboxylic acid methyl ester in 4 ml THF was added 1.20 ml (1.20 mmol) i N sodium hydroxide and the mixture was stirred at room temperature for 29 h. To the mixture were added 1.09 ml (1.09 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.

Aufarbeitung

  1. additionwas added
  2. customthe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-ae70d9e4fbc240f39dbb9fefd5283c58
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846658B2

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