Dimethylamine tetrahydrofuran → 6-({3-chloro-5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-(5-methylpyrazin-2-yl)quinazoline-4-amine

HRID 81649

Reaktionsgleichung

Reaktionsgleichung von HRID 81649
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=3)[N:12]=[CH:11][N:10]=2)=[N:6][CH:7]=1.[Cl:20][C:21]1[C:22](F)=[N:23][CH:24]=[C:25]([O:27][CH2:28][CH:29](OCC)OCC)[CH:26]=1.[CH3:37][NH:38][CH3:39].O1CCCC1>>[Cl:20][C:21]1[C:22]([O:19][C:16]2[CH:17]=[C:18]3[C:13](=[CH:14][CH:15]=2)[N:12]=[CH:11][N:10]=[C:9]3[NH:8][C:5]2[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][N:6]=2)=[N:23][CH:24]=[C:25]([O:27][CH2:28][CH2:29][N:38]([CH3:39])[CH3:37])[CH:26]=1

Komponenten

4

Edukt 3

HCID 22320367Dimethylamine tetrahydrofuranHCID 684276023-Chloro-5-(2,2-diethoxyethoxy)-2-fluoropyridineHCID 1356182224-((5-Methylpyrazin-2-yl)amino)quinazolin-6-ol

Produkt 1

HCID 595088676-({3-chloro-5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-(5-methylpyrazin-2-yl)quinazoline-4-amine

Versuchsvorschrift

Using 4-[(5-methylpyrazin-2-yl)amino]quinazolin-6-ol, 3-chloro-5-(2,2-diethoxyethoxy)-2-fluoropyridine and 2 M dimethylamine/tetrahydrofuran solution, and in the same manner as in Example 32 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (14 mg) was obtained as a pale yellow amorphous solid.

Quellen und Nachweise

ORD-Eintrag
ord-5b3fb5f4479042eba32fefa1955e7f91
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846700B2

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