HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Trifluoroiodomethane | HCID 16843 | — |
| Edukt | Potassium Fluoride | HCID 522689 | — |
| Edukt | 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene | HCID 67053452 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene | HCID 67053481 | 107,9% |
Reaktionsschritte
To a hot mixture of 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (0.5 g, 1.12 mmol), CuI, KF in anhydrous DMF (10 ml) at 120° C. oil bath temperature, was added trifluoromethyl iodide (0.64 g, 4.48 mmol) in portions over 30 min. The reaction mixture was heated for 4 hrs and poured into H2O (100 ml). The insoluble solid, which was collected by filtration was triturated with methylene chloride, filtered and concentrated to give 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene (0.45 g, 100%) as a solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846705B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-32ee993b2ce6444b8cac3160215421e4 |
| Quellennotiz | uspto-grants-2014_09 |