HCID 9817345, Verbindung → HCID 57557295, Verbindung

HRID 81944

Reaktionsgleichung

Reaktionsgleichung von HRID 81944
[NH2:1][C@H:2]([C:6](OCC1N(CCCCNS(C)(=O)=O)C2C3C=CC=CC=3N=C(N)C=2N=1)=[O:7])[CH:3]([CH3:5])[CH3:4].[NH2:33][C:34]1[C:43]2[N:44]=[C:45]([CH2:52][OH:53])[N:46]([CH2:47][C:48]([CH3:51])([OH:50])[CH3:49])[C:42]=2[C:41]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[N:35]=1.NC1C2N=C(CO)N(CCCCNS(C)(=O)=O)C=2C2C=CC=CC=2N=1>>[NH2:1][C@H:2]([C:6]([O:53][CH2:52][C:45]1[N:46]([CH2:47][C:48]([OH:50])([CH3:49])[CH3:51])[C:42]2[C:41]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[N:35]=[C:34]([NH2:33])[C:43]=2[N:44]=1)=[O:7])[CH:3]([CH3:5])[CH3:4]

Komponenten

4

Edukt 3

HCID 9817345HCID 9817345, VerbindungHCID 11856399N-[4-(4-amino-2-hydroxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamideHCID 57555835(4-amino-1-{4-[(methylsulfonyl)amino]butyl}-1H-imidazo[4,5-c]quinolin-2-yl)methyl L-valinate

Produkt 1

HCID 57557295HCID 57557295, Verbindung

Versuchsvorschrift

[4-Amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl]methyl L-valinate was prepared according to the general method used to prepare (4-amino-1-{4-{(methylsulfonyl)amino]butyl}-1H-imidazo[4,5-c]quinolin-2-yl)methyl L-valinate using 1-(4-amino-2-hydroxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol in lieu of N-[4-(4-amino-2-hydroxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide. The product was provided as off-white needles, mp 190-192° C.; MS (ESI) m/z 386 (M+H); Anal. Calcd for C20H27N5O3: C, 62.32; H, 7.06; N, 18.17. Found C, 62.08; H, 7.11; N, 17.96.

Aufarbeitung

  1. customThe product was provided as off-white needles, mp 190-192° C.

Quellen und Nachweise

ORD-Eintrag
ord-5ce59781ca5a44b390e4d48b2007a065
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846710B2

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