7-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amine → 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine

HRID 81987

Reaktionsgleichung

Reaktionsgleichung von HRID 81987
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:20][CH:21]([CH3:25])[CH2:22][O:23][CH3:24])=[C:12]([N+:17]([O-])=O)[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:26][CH3:27])=[C:5]([CH3:28])[O:4][N:3]=1.[H][H]>CCOC(C)=O>[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:20][CH:21]([CH3:25])[CH2:22][O:23][CH3:24])=[C:12]([NH2:17])[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:26][CH3:27])=[C:5]([CH3:28])[O:4][N:3]=1

Komponenten

4

Edukt 2

HCID 709805047-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 709803797-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amine (0.80 g, 2.070 mmol) was dissolved in EtOAc (120 ml) and hydrogenated using a flow hydrogenation apparatus (H Cube™, settings: full hydrogen, atmospheric pressure, 1 ml/min flow rate). The eluant was evaporated in vacuo to give the title compound as an orange gum (0.73 g, 99%). LCMS (formate) Rt 0.73 min, MH+ 357.

Aufarbeitung

  1. customThe eluant was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-99b2ec67f7b749ba882bc78e4e59ac4f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846709B2

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