Trifluoroacetic acid → HCID 66571343, Verbindung

HRID 82004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 82004
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:18][CH:19]([CH3:23])[CH2:20][O:21][CH3:22])=[C:12]([NH2:17])[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:24][CH3:25])=[C:5]([CH3:26])[O:4][N:3]=1.[N:27]([CH2:30][CH2:31][NH:32]C(=O)OC(C)(C)C)=[C:28]=S.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C:2]1[C:6]([C:7]2[C:8]([O:24][CH3:25])=[CH:9][C:10]3[C:11]4[N:18]([CH:19]([CH3:23])[CH2:20][O:21][CH3:22])[C:28]([NH:27][CH2:30][CH2:31][NH2:32])=[N:17][C:12]=4[CH:13]=[N:14][C:15]=3[CH:16]=2)=[C:5]([CH3:26])[O:4][N:3]=1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 4219896N-Boc-2-isothiocyanatoethylamineHCID 709803797-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine

Produkt 1

HCID 66571343HCID 66571343, VerbindungAusbeute 5,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

From 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine (70 mg) and 1,1-dimethylethyl (2-isothiocyanatoethyl)carbamate (50 mg). The crude product isolated was treated with TFA (2 ml) in DCM (10 ml), the mixture stirred for 1 h, then evaporated in vacuo. The residue was dissolved in DMSO (1 ml) and purified by MDAP (HpH) to give the title compound as a beige solid (4.5 mg, 4%).

Aufarbeitung

  1. customThe crude product isolated
  2. customevaporated in vacuo
  3. dissolutionThe residue was dissolved in DMSO (1 ml)
  4. custompurified by MDAP (HpH)

Quellen und Nachweise

ORD-Eintrag
ord-a710c874c58c4418bcf6ffcc994443fc
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846709B2

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