1,4-Dioxane hydrochloride → 2-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide

HRID 82119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 82119
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:32]C(=O)OC(C)(C)C)[C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=3)=[O:19])[CH:17]=2)=[O:10])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[NH2:32][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:9]([NH:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]2[C:28]3[CH:27]=[N:26][CH:25]=[N:24][C:23]=3[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=2)=[O:19])[CH:17]=1)=[O:10]

Komponenten

3

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70856232tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate

Produkt 1

HCID 708179792-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamideAusbeute 8 %

Versuchsvorschrift

To tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate (Preparation 299, 64 mg, 0.11 mmol) was added 4M HCl/dioxane (5 mL) and the reaction stirred at room temperature for 18 hours. The mixture was evaporated in vacuo and purified by preparative reverse phase HPLC to give the title compound as a beige solid in 8% yield, 4 mg.

Aufarbeitung

  1. customThe mixture was evaporated in vacuo
  2. custompurified by preparative reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-af974f211c1f4c598f549ccae4a71d68
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846698B2

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