2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → N-[2-Ethoxy-5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetamide

HRID 82127

Reaktionsgleichung

Reaktionsgleichung von HRID 82127
[NH2:1][C:2]1[CH:3]=[C:4]([C:11]([C:13]2[C:21]3[CH:20]=[N:19][CH:18]=[N:17][C:16]=3[N:15]([CH:22]([CH3:24])[CH3:23])[CH:14]=2)=[O:12])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH3:10].[CH3:25][C:26]1[N:30]([CH2:31][C:32](O)=[O:33])[N:29]=[C:28]([C:35]([F:38])([F:37])[F:36])[CH:27]=1>>[CH2:9]([O:8][C:7]1[C:2]([NH:1][C:32](=[O:33])[CH2:31][N:30]2[C:26]([CH3:25])=[CH:27][C:28]([C:35]([F:38])([F:37])[F:36])=[N:29]2)=[CH:3][C:4]([C:11]([C:13]2[C:21]3[CH:20]=[N:19][CH:18]=[N:17][C:16]=3[N:15]([CH:22]([CH3:23])[CH3:24])[CH:14]=2)=[O:12])=[CH:5][N:6]=1)[CH3:10]

Komponenten

3

Edukt 2

HCID 5961182-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 70817179(5-Amino-6-ethoxy-pyridin-3-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Produkt 1

HCID 70817762N-[2-Ethoxy-5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetamide

Versuchsvorschrift

The title compound was prepared according to the method described for Example 1 using (5-Amino-6-ethoxy-pyridin-3-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone (Preparation 242) and (5-Methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid to afford the title compound as off white solid in 50% yield, 40 mg.

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-e1f7abc9b8df459e881d52131cd44450
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846698B2

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