4-Cyanophenylacetic acid → N-[5-(2-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-cyano-phenyl)-acetamide

HRID 82128

Reaktionsgleichung

Reaktionsgleichung von HRID 82128
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]([C:13]3[CH:14]=[N:15][CH:16]=[C:17]([NH2:19])[CH:18]=3)=[O:12])=[CH:9][N:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:6]=2[N:7]=1.[C:24]([C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33](O)=[O:34])=[CH:28][CH:27]=1)#[N:25]>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]([C:13]3[CH:18]=[C:17]([NH:19][C:33](=[O:34])[CH2:32][C:29]4[CH:30]=[CH:31][C:26]([C:24]#[N:25])=[CH:27][CH:28]=4)[CH:16]=[N:15][CH:14]=3)=[O:12])=[CH:9][N:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:6]=2[N:7]=1

Komponenten

3

Edukt 2

HCID 795874-Cyanophenylacetic acidHCID 70817234(2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone

Produkt 1

HCID 70817957N-[5-(2-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-cyano-phenyl)-acetamide

Versuchsvorschrift

The title compound was prepared according to the method described for Example 1 using (2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone (see Preparation 65) and 4-cyano phenyl acetic acid to afford the title compound as off white solid in 58%, 23 mg.

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-2cfc86e2739b4fc9a520718e8ac0f6d0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846698B2

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