(R)-(-)-2-Amino-1-propanol → (2R)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

Reaktionsgleichung

Cl[C:2]1[C:7]([CH2:8][CH:9]=O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[NH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[Cl:11][C:6]1[C:7]2[CH:8]=[CH:9][N:12]([C@H:13]([CH3:16])[CH2:14][OH:15])[C:2]=2[N:3]=[CH:4][N:5]=1

Komponenten

Edukt 2

HCID 80308(R)-(-)-2-Amino-1-propanol

HCID 13989292(4,6-Dichloropyrimidin-5-yl)acetaldehyde

Produkt 1

HCID 86672074(2R)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

Versuchsvorschrift

The title compound was prepared according to the method described for Preparation 1 using (4,6-dichloropyrimidin-5-yl)acetaldehyde and (R)-2-amino-1-propanol to afford the title compound as a yellow solid in 100% yield, 11.12 g.

Aufarbeitung

customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag: ord-724f7da987ad489a87231b8b832ce6de
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08846698B2

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