7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine → [7-(2-{[tert-Butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]{5-[(diphenylmethylene)amino]pyridin-3-yl}methanone
Reaktionsgleichung
[Si:1]([O:8][CH2:9][C:10]([N:13]1[C:17]2[N:18]=[CH:19][N:20]=[CH:21][C:16]=2[C:15](I)=[CH:14]1)([CH3:12])[CH3:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:23]1([C:29](=[N:36][C:37]2[CH:38]=[N:39][CH:40]=[C:41]([CH:48]=2)[C:42](N(OC)C)=[O:43])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[Si:1]([O:8][CH2:9][C:10]([N:13]1[C:17]2[N:18]=[CH:19][N:20]=[CH:21][C:16]=2[C:15]([C:42]([C:41]2[CH:40]=[N:39][CH:38]=[C:37]([N:36]=[C:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:48]=2)=[O:43])=[CH:14]1)([CH3:12])[CH3:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared according to the method described for Preparation 24 using 7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (see Preparation 15) and 5-[(diphenylmethylene)amino]-N-methoxy-N-methylnicotinamide (see Preparation 23) to afford the title compound as a colourless gum in 56% yield, 1.49 g.