Hydrochloric Acid → 2-(1H-indazol-6-yl)acetic acid

HRID 82224

Reaktionsgleichung

Reaktionsgleichung von HRID 82224
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:9]=2)[CH:4]=[N:3]1>O1CCOCC1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([OH:14])=[O:13])[CH:9]=2)[CH:4]=[N:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70817797tert-Butyl 1H-indazol-6-ylacetate

Produkt 1

HCID 595093302-(1H-indazol-6-yl)acetic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Hydrochloric acid (10 mL, 4 M in 1.4 dioxane) was added to tert-butyl 1H-indazol-6-ylacetate (Preparation 181, 1.00 g, 4.3 mmol) in 1,4 dioxane (5 mL) at 0° C. and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the residue was triturated with dry ether to afford the title compound as a white solid in 100% yield, 800 mg.

Aufarbeitung

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was triturated with dry ether

Quellen und Nachweise

ORD-Eintrag
ord-3c81c2c5bc02478a93749e62b6b767fe
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846698B2

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