Hydrochloric Acid → Hydrochloric Acid
Reaktionsgleichung
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH2:17][C:16]2[N:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[N:15]1[C:16]2[CH2:17][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH2:9][CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1.[ClH:19]Komponenten
5
Edukt 2
Produkt 2
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
(5,8-Dihydro-6H-[1,7]naphthyridin-7-yl)-acetic acid tert-butyl ester (Preparation 234, 1.25 g, 5.03 mmol) was treated with 4N HCl in dioxane (25 ml) at room temperature for 2 hours. The mixture was evaporated to dryness in vacuo and the solid residue was triturated with diethyl ether to afford the title compound as white solid in 78% yield (calculated as HCl salt), 900 mg.
Aufarbeitung
- customThe mixture was evaporated to dryness in vacuo
- customthe solid residue was triturated with diethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-a887addf18ec438d898b6b222f312670
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846698B2
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