Ether, ethyl ethynyl → [2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Ether, ethyl ethynyl	HCID 61239	—
Edukt	Benzcatechinborane	HCID 6327445	—
Edukt	(5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine	HCID 86672124	—
Produkt	[2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine	HCID 86672125	—

Reaktionsschritte

The title compound was prepared according to the method described for Preparation 61 using (5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine (Preparation 256), catechol borane and ethoxyacetylene (40% in hexane) to afford the title compound as light brown gum in 44% yield, 2.6 g.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08846698B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-1ce22986ba4a440495b30bf3ade47f58
Quellennotiz	uspto-grants-2014_09